Global Functional Atlas of Escherichia coli Encompassing Previously Uncharacterized Proteins
نویسندگان
چکیده
منابع مشابه
Global Functional Atlas of Escherichia coli Encompassing Previously Uncharacterized Proteins
One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally unannotated (orphans). Many map to distant clades such as Archaea, suggesting involvement in basic prokaryotic traits, whereas others appear restricted to E. coli, including pathogenic strains. To elucidate the orphans' biological roles, we performed an extensive proteomic survey using affinity-tagged E. co...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2009
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000096